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J Occup Health year 1997 volume 39 number 2 page 119 - 123
Classification Original
Title Therapeutic Efficacy of a Few Diesters of Meso 2,3-Dimercaptosuccinic Acid during Sub-Chronic Arsenic Intoxication in Rats
Author S.J.S. Flora1, B.P. Pant2, Neelima Tripathi1, G.M. Kannan1 and D.K. Jaiswal2
Organization 1Division of Pharmacology and Toxicology and
2Division of Chemistry, Defence Research and Development Establishment
Keywords Arsenic toxicity, Sub-chronic exposure, Biochemical alteration, Arsenic concentration, Chelation, Diesters, Rats
Correspondence
Abstract Therapeutic Efficacy of a Few Diesters of Meso 2,3-Dimercaptosuccinic Acid during Sub-Chronic Arsenic Intoxication in Rats: S.J.S. Flora, et al. Division of Pharmacology and Toxicology, Defence Research and Development Establishment-The therapeutic efficacy of four diesters derivatives of meso 2,3-dimercaptosuccinic acid (DMSA) was investigated in subchronic arsenic intoxication in rats. Dimethyl DMSA (DMDMSA), diethyl DMSA (DEDMSA), diisopropyl DMSA (DiPDMSA) and diisoamyl DMSA (DiADMSA) were the diesters of DMSA with methyl, ethyl, isopropyl and isoamyl alcohols and were administered for two 5 day courses of treatment in male rats pre-exposed to 100 ppm arsenic (III) for 8 weeks. The results show that treatment with these diesters was effective in decreasing blood and soft tissue arsenic contents but was only moderately effective in recovering biochemical indicators. The results suggest that these diesters could be effective arsenic chelators but may be inferior to DMSA in recovering biochemical/clinical indicators following sub-chronic arsenic exposure.