Classification

Originals

Dermal and Bronchial Responsiveness of Aluminum Smelter Workers

Title

Author

Evgenije HOSOVSKl, et al

Health Center, Department of Occupational Medicine Uzice

Aluminum-adverse-effects, Bronchial responsiveness, Dermal-sensitiveness, Immunoglobulins
E. Hosovski, ul Dimitrija Tucovica br 44/stan 13, 31000-Uzice, Yugoslavia

Organization

Keywords

Correspondence

-

year

1998

Vol

40

No

1

44

49

J Occup Health

Tests on dermal and bronchial responsiveness were carried out in aluminum smelter workers (exposed group, n=127), and in office workers (control group, n=49). All the participants were male, apparently healthy and tobacco non-smokers. The studied groups were comparable for all parameters used but not for occupational environment conditions (i.e. aluminum and other toxic noxae exposure). Patch and prick cutaneous test revealed hypersensitive reaction to pure aluminum, aluminum smelter dust, and histamine in a significant number of exposed workers. Bronchial hyper responsiveness to acetylcholine (but not to aluminum aerosol) was found in 38.5% of exposed workers versus 2.0% of the control group. The research showed that mean values for IgA and IgG (but not IgE and IgM), were considerably higher in the serum of exposed workers. In respect to genetic markers, no important difference between the groups studied in alpha-1-anti-trypsin values in serum was noted. The changes noted lead to the conclusion that there is an immunological disturbance in workers exposed for a long time to toxic compounds (mainly aluminum) in an aluminum smelter. Present knowledge cannot explain these findings by the adverse effects of aluminum alone.

Abstract