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The Effects of Allyl Chloride on Ca2+, Ca2+-Free CaM, cAMP and Ca2+/CaM-PK II Activity in Nerve Cells

Keqin XIE, et al

Institute of Toxicology, Shandong Medical University

Allyl chloride, Nerve cell, Ca2+, CaM, cAMP, Ca2+/CaM-PK II, Neurotoxicity K. Xie, Institute of Toxicology, Shandong Medical University, Jinan 250012, P.R. China J Occup Healthyear1998Vol40No150-54

Nerve cells in a culture from chicken embryo brain were used to study the allyl chloride-induced effects on the contents of intracellular Ca2+, Ca2+-free CaM, cAMP and the activity of Ca2+/CaM-PK II. The results showed that with the increase in the concentration of allyl chloride there was a significant increase in the content of Ca2+and cAMP, and the activity of Ca2+/CaM-PK II in the cells (P<0.01), but a marked decease in Ca2+-free CaM (P<0.01). The results suggest that the neurotoxicity of allyl chloride might be related to the increase in intra-cellular Ca2+ and the activation of CaM and Ca2+/CaM-PK II, eventually leading to the accumulation of degenerative MT in the nerve axon.

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