Get full text report (pdf file; Read by ADOBE Acrobat Reader)
J Occup Health year 2001 volume 43 number 6 page 307 - 313
Classification Original
Title Trans-Cranial Doppler and Peripheral Sensory Threshold Tests for Carbon Disulfide Poisoning
Author Eunil LEE1, Hun-Jong CHUNG1, Soon-Duck KIM1, Jong-Tae PARK1, Donggeun SUL1 and Myung-Hyun KIM2
Organization 1Department of Preventive Medicine, School of Medicine and Institute for Environmental Health, Medical Science Research Center, Korea University,
2Department of Neurosurgery, School of Medicine, Ewha Women's University
Keywords Carbon disulfide, Trans-cranial doppler songography, Sensory threshold
Correspondence E. Lee, Department of Preventive Medicine, School of Medicine, Korea University, 126-1, 5-ka, Anam-Dong, Sungbuk-Ku, Seoul 136-705, Korea
Abstract Trans-Cranial Doppler and Peripheral Sensory Threshold Tests for Carbon Disulfide Poisoning: Eunil LEE, et al. Department of Preventive Medicine, School of Medicine, Korea University-Trans-cranial doppler (TCD) and sensory threshold (vibration, pain and discrimination) tests, which are safe and inexpensive techniques, were applied to detect cerebral vasoreactivity or neuropathic changes between carbon disulfide (CS2) poisoning cases and two control groups respectively. The cases were 31 male CS2 poisoning workers, and the first control group for the TCD test consisted of eight healthy men, and the second group for the threshold test were 21 healthy male workers. In the TCD test, the blood flow velocity in both middle cerebral arteries and the CO2 content of expired air were measured to evaluate CO2 reactivity. The vibration and pain perception threshold were measured on both the 2nd and 5th fingers. The CS2 poisoning cases showed higher rates of abnormal CO2 reactivity above the cut-off value than healthy controls (80.0-81.8% vs 0%). Among the threshold tests, the proportions of abnormal pain threshold of both the 2nd and 5th fingers were higher in poisoning cases than in the controls (77.8%-88.9% vs 11.1-33.3%) among over 45 yr old subjects. CO2 reactivity and pain threshold test showed the possibility to detect changes in cerebral vessels and the sensory threshold in CS2 exposure cases, but there should be further study to apply these tests to workers exposed to CS2 before the development of CS2 poisoning, with large number of control subjects.