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J Occup Health year 2001 volume 43 number 6 page 346 - 350
Classification Original
Title Protective Effect of Clonidine against Toxicity of Organophosphorus Pesticides
Author Zhijun ZHOU, Yunping HU, Yunguang SUN and Jia CHEN
Organization Department of Occupational Health and Toxicology, School of Public Health, Fudan University
Keywords Clonidine, Organophosphate, Experimental therapy
Correspondence Z. Zhou, Department of Occupational Health and Toxicology, School of Public Health, Fudan University, 130 Dong An Road, Shanghai 200032, China
Abstract Protective Effect of Clonidine against Toxicity of Organophosphorus Pesticides: Zhijun ZHOU, et al. Department of Occupational Health and Toxicology, School of Public Health, Fudan University-Aim: The purpose of this study was to check whether clonidine, a centrally active alpha-2 adrenergic agonist, could serve as an antagonist against the acute toxicity of generally used organophosphorus pesticides (OP) in laboratory animals. Methods: The tests of three factors, the dose level of pesticide, and the administration schedules for atropine and clonidine, were arranged for cross-checking according to three level orthogonal layouts. The latency of onset of apparent body tremor, loss of righting reflex and survival time was timed. Results: The survival time was longest in the treatments with 5 mg/kg atropine, 20 min pre- OP injection or with 1 mg/kg clonidine, 10 min pre-OP injection. The latency of onset of apparent body tremor and the loss of righting reflex were prolonged when clonidine or atropine was given before OP administration. Conclusion: These results indicated that the use of clonidine in the clinical treatment of intoxication by means of organophosphates is reasonable and acceptable. It is a recommendation of a new use of an old drug. Used cautiously, beneficial effects of clonidine could be expected, either separately or combined with atropine, in the treatment of organophosphate intoxication.