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J Occup Health year 2004 volume 46 number 5 page 365 - 373
Classification Original
Title Association between Cigarette Consumption and Proteinuria in Healthy Japanese Men and Women from an Occupational Population
Author Yuichi YAMADA1, Yuka NOBORISAKA1, Masao ISHIZAKI1, Ryumon HONDA1, Ikiko TSURITANI1 and Seiji YAMADA2
Organization 1Department of Social and Environmental Medicine (Hygiene), Kanazawa Medical University and 2Matsushita Science Center of Industrial Hygiene, Japan
Keywords Cigarette consumption, Proteinuria, Blood pressure, Occupational population, Hypertension, Diabetes mellitus
Correspondence Y. Yamada, Department of Social and Environmental Medicine (Hygiene), Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan (e-mail: u1yamada@kanazawa-med.ac.jp)
Abstract Association between Cigarette Consumption and Proteinuria in Healthy Japanese Men and Women from an Occupational Population: Yuichi YAMADA, et al. Department of Social and Environmental Medicine (Hygiene), Kanazawa Medical University-The association between cigarette consumption and prevalence of mild proteinuria (30-99 mg/dl of albumin) was analyzed in 11,569 male and 4,715 female workers aged 18-67 yr recruited from an occupational population. Proteinuria was found in 274 (2.4%) of the total male workers and in 50 (1.1%) of the total females. Stepwise logistic regression analyses showed that sex, suspected diabetes mellitus, blood pressure (BP) and Brinkman Index (BI) levels (0, 1-199, 200-499, 500-799, 800-) were significantly related to proteinuria, and that the odds ratio of each BI level for proteinuria was 1.11 (C.I.: 1.01-1.67). In the subjects aged 50 yr or older, after excluding those suspected of having hypertension and/or diabetes mellitus, the odds ratio reached 1.37 (C.I.: 1.15-1.63), with the gender difference then no longer significant. The odds ratio for proteinuria was calculated as 5.44 (C.I.: 2.27-13.0) in male and female smokers having a BI of 500 or above and normal-high BP (130-139/85-89 mmHg) in comparison with nonsmokers having normal BP (<130/85 mmHg). These results suggest that heavy cigarette consumption represented by a BI of 500 or above is a risk factor of proteinuria even in healthy Japanese workers, particularly in those aged 50 yr or older and having normal-high BP.