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J Occup Health year 2005 volume 47 number 1 page 68 - 73
Classification Original
Title Whole Blood and Red Blood Cell Manganese Reflected Signal Intensities of T1-Weighted Magnetic Resonance Images better than Plasma Manganese in Liver Cirrhotics
Author Younghee CHOI1, Ji Kang PARK2, Neung Hwa PARK3, Jung Woo SHIN3, Cheol-In YOO1, Choong Ryeol LEE1, Hun LEE1, Hyo Kyung KIM4, Sung-Ryul KIM5, Tae-hum JUNG6, Jungsun PARK7, Chung Sik YOON8 and Yangho KIM1
Organization 1Department of Occupational and Environmental Medicine, 2Department of Radiology, 3Department of Internal Medicine, 4Department of Neurology, 5Department of Clinical Pathology, 6Department of Family Medicine, Ulsan University Hospital, 7Korea Occupational Safety and Health Agency and 8Department of Occupational Health, Catholic University of Daegu, South Korea
Keywords Manganese, Signal intensity, Magnetic resonance, Liver cirrhosis, Pallidal index
Correspondence Y. Kim, Department of Occupational and Environmental Medicine, Ulsan University Hospital, #290-3 Cheonha-Dong, Dong-Ku, Ulsan, 682-060, South Korea
(e-mail: yanghokm@nuri.net)
Abstract Whole Blood and Red Blood Cell Manganese Reflected Signal Intensities of T1-Weighted Magnetic Resonance Images better than Plasma Manganese in Liver Cirrhotics: Younghee CHOI, et al. Department of Occupational and Environmental Medicine, Ulsan University Hospital, South Korea-We examined whole blood (MnB), red blood cell (MnRBC), plasma (MnP) and urinary Mn (MnU) concentrations in 22 liver cirrhotics and 10 healthy controls to evaluate Mn concentration in which a fraction of biological samples best reflects pallidal signal intensities (pallidal index; PI) on T1-weighted magnetic resonance images (MRI) in liver cirrhotics. Increased signal intensity in the globus pallidus was observed in 18 (81.8%) of the 22 patients with liver cirrhosis. In a transplanted patient, increased pallidal signals also resolved as his liver function tests normalized after liver transplantation. There were significant correlations between MnB/MnRBC and PI (p=0.529, p=0.573, respectively) in liver cirrhotics, although no significant correlation was observed between MnP/MnU and PI. According to a multiple linear regression, MnB and MnRBC reflected the signal intensities of T1-weighted MRI better than MnP or MnU.