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J Occup Health year 2006 volume 48 number 3 page 198 - 206
Classification Original
Title An Inverse Association between Serum Gamma Glutamyl Transpeptidase Activity and Breslow's Lifestyle Index; Its Practical Application for Screening of Subjects with Unhealthy Lifestyles
Author Hirokazu YOKOYAMA1, 2, Hideki OHGO2, Hiroshi HIROSE1, Susumu MORIYA2, Toshifumi HIBI2 and Ikuo SAITO1
Organization 1Health Center and 2Department of Gastroenterology, School of Medicine, Keio University, Japan
Keywords gammaGTP, Breslow's index, Lifestyle-related diseases, Insulin resistance, Ethanol
Correspondence H. Yokoyama, Yotsuya Office, Health Center, Keio University, 35 Shinanomachi, Shinjukuku, Tokyo 160-8582, Japan (e-mail: yokoyama@sc.itc.keio.ac.jp)
Abstract An Inverse Association between Serum Gamma Glutamyl Transpeptidase Activity and Breslow's Lifestyle Index; Its Practical Application for Screening of Subjects with Unhealthy Lifestyles: Hirokazu YOKOYAMA, et al. Health Center, School of Medicine, Keio University-We examined whether serum gammaGTP activity (gammaGTP) is associated with Breslow's lifestyle index and whether it could be used as a tool to detect subjects with unhealthy lifestyles. To that effect, 724 male Japanese workers excluding patients suffering from hepatitis virus infection, autoimmune liver diseases and apparently active bile duct diseases were cross-sectionally examined. gammaGTP was inversely associated with the total score of Breslow's index for all subjects (=30.643) and in subjects aged 40 or more (=37.073). The association was consistent even after adjustments of subjects' ages and levels of triglycerides, total cholesterol and uric acid (p=0.0001). Among the seven lifestyle factors comprising Breslow's index, improper habits of drinking (p<0.0001), smoking (p=0.0204), exercise (p=0.0189) and body weight control (p<0.0001), were associated with increased gammaGTP. Even in a survey in which subjects who had proper habits of drinking and body weight control were selectively examined, improper habits of smoking and exercise still tended to be associated with increased gammaGTP. Receiver operating characteristic curves indicated that gammaGTP was beneficial for detecting subjects who scored two or less on Breslow's index, at least in subjects aged 40 or more. gammaGTP was associated with insulin resistance level estimated by the homeostasis model assessment (p<0.0001), which was inversely associated with Breslow's index (p=0.0040). gammaGTP could be used as an objective substitute of Breslow's index, allowing us to identify subjects with low scores on Breslow's index, at least after sorting subjects properly. Such screening would enable interventions to correct subjects' unhealthy lifestyles, helping to solve lifestyle-related disease issues.