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J Occup Health year 2007 volume 49 number 2 page 159 - 164
Classification Field Study
Title Analysis of Urinary Metabolites of Polycyclic Aromatic Hydrocarbons in Incineration Workers
Author Masayoshi ICHIBA1, Yasutaka OGAWA2, Ippei MOHRI2, Toshihiro KONDOH3, Mikako HORITA1, Akiko MATSUMOTO1, Rie YOSHIDA2, Yuki MATSUMOTO2, Hiroyuki SAITO2, Ken-ichi OHBA2, Zenkoh YAMASHITA1 and Katsumaro TOMOKUNI1
Organization 1Department of Social and Environmental Medicine, Saga Medical School, 2National Institute of Occupational Safety and Health and 3Analytical Research and Experiment Center, Saga Medical School, Japan
Keywords Polycyclic aromatic hydrocarbon, Incineration workers, 1-hydroxypyrene, 2-naphthol
Correspondence M. Ichiba, Department of Social and Environmental Medicine, Saga Medical School, Nabeshima, Saga 849-8501, Japan (e-mail: ichiba@cc.saga-u.ac.jp )
Abstract Analysis of Urinary Metabolites of Polycyclic Aromatic Hydrocarbons in Incineration Workers: Masayoshi ICHIBA, et al. Department of Social and Environmental Medicine, Saga Medical School-Incineration workers are exposed to various pyrolysis products of organic materials, heavy metals and polycyclic aromatic hydrocarbons (PAHs). In this study, the exposure of incineration workers to PAHs was evaluated by measuring urinary metabolites of pyrene and naphthalene. The concentrations of urinary 1-hydroxypyrene (1OHP), a metabolite of pyrene, and 2-naphthol (2NP), a metabolite of naphthalene, were measured among 100 workers in 4 different types of incinerators, both before and after their work shifts. These incinerators were two old types, one modern type and one outdoors. The medians of urinary 1OHP of before and after the work shifts obtained from all workers were 0.067 and 0.044 microg/gCr, respectively; and the medians of urinary 2NP were 7.5 and 10.0 microg/gCr, respectively. A significant increase of 2NP after the work shift was found at one old incinerator. A significant decrease of metabolites was found at the other old incinerator. Significant correlations were found between urinary metabolites and cigarettes smoked per day. The effect of smoking on urinary metabolite levels was also important. Significant correlations were found between urinary 1OHP and 2NP levels in all workers. In multiple regression analysis smoking habit and incinerator type were found as significant factors. The improvement of the work environment, through decreasing exposure to both tobacco smoke and hazardous work shift-related substances, should be an occupational health aim.