Get full text report (pdf file; Read by ADOBE Acrobat Reader)
J Occup Health year 2007 volume 49 number 5 page 353 - 362
Classification Original
Title Differential Effects of Aging, Drinking and Exercise on Serum Cholesterol Levels Dependent on the PPARA-V227A Polymorphism
Author Hisao NAITO1, Michihiro KAMIJIMA1, Osamu YAMANOSHITA2, Ai NAKAHARA3, Takahiko KATOH3, Naoki TANAKA4, Toshifumi AOYAMA4, Frank J. ONZALEZ5
and Tamie NAKAJIMA1
Organization 1Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 2Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 3Department of Public Health, Miyazaki Medical College, University of Miyazaki, 4Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Japan and 5Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, USA
Keywords Peroxisome proliferator-activated receptor alpha, Alcohol drinking, Aging, Exercise, Polymorphism, Molecular epidemiology, Cholesterol, Sex, Japanese
Correspondence T. Nakajima, Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
(e-mail: tnasu23@med.nagoya-u.ac.jp)
Abstract Differential Effects of Aging, Drinking and Exercise on Serum Cholesterol Levels Dependent on the PPARA-V227A Polymorphism: Hisao NAITO, et al. Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine-Peroxisome proliferator-activated receptor (PPAR alpha) plays a pivotal role in lipid metabolism. Our previous study reported that PPARA-V227A was a major polymorphism in Japanese, which was associated with markedly lower serum total cholesterol (TC) levels, which were significantly affected by alcohol drinking compared to subjects with the wild-type (PPARA-WT) allele. However, serum lipids are also associated with aging and exercise frequency. The objective of the present study was to evaluate the relationship between PPARA-V227A and these factors. Genetic analysis of the polymorphism was performed in 1058 Japanese men and 281 women, and the relationship with aging, drinking and exercise on serum lipids was analyzed in 989 men and 245 women after exclusion criteria had been applied. In men, drinking increased high-density lipoprotein cholesterol (HDL-C) levels in both PPARA-WT and A227 carriers, but to a significantly higher degree in the latter. In women, TC and low-density lipoprotein cholesterol (LDL-C) levels in the A227 carriers drinking at least once a week were significantly higher than in PPARA-WT carriers. TC and LDL-C levels in males with PPARA-WT increased with aging regardless of drinking habit, while LDL-C levels in the A227 drinking carriers were significantly lower in 45-yr-old or older subjects than in 35- to 45-yr-olds. In addition, no effect of exercising was observed in the A227 carriers, while increase in the HDL-C of the PPARA-WT carriers was exercise frequency dependent. These results suggest that the influence of drinking, aging or exercise on TC, LDL-C and HDL-C levels in the A227 carriers may be different from those in the PPARA-WT subjects.