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J Occup Health year 2008 volume 50 number 1 page 1 - 6
Classification Rapid communication
Title Body Distribution of Inhaled Fluorescent Magnetic Nanoparticles  in the Mice
Author Jung-Taek KWON1, Soon-Kyung HWANG1, Hua JIN1, Dae-Seong KIM3, Arash MINAI-TEHRANI1,
Hee-Jeong YOON1, Mansoo CHOI3, Tae-Jong YOON4, Duk-Young HAN5, Young-Woon KANG5,
Byung-Il YOON6, Jin-Kyu LEE2,4 and Myung-Haing CHO1,2
Organization 1Laboratory of Toxicology, College of Veterinary Medicine, 2Nano Systems Institute-National Core Research
Center, 3Nanotechnology & Thermal Processing Laboratory, School of Mechanical and Aerospace Engineering,
4Materials Chemistry Laboratory, School of Chemistry, Seoul National University, 5Seoul Center, Korea Basic
Science Institute and 6School of Veterinary Medicine, Kangwon National University, Republic of Korea
Keywords Fluorescent Magnetic Nanoparticles,  Inhalation, Mice
Correspondence M.-H. Cho, Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 151-742,
Korea (e-mail:
Abstract Reducing the particle size of materials is an efficient and reliable tool for improving the bioavailability of a gene or drug delivery system. In fact,  nanotechnology helps in overcoming the limitations of size and can change the outlook of the world regarding science. However, a potential harmful effect of  nanomaterial on workers manufacturing nanoparticles
is expected in the workplace and the lack of information regarding body distribution of inhaled nanoparticles may pose serious problem. In this study, we addressed this question by studying the body distribution of inhaled nanoparticles in mice using approximately 50-nm fluorescent magnetic nanoparticles (FMNPs) as a model of nanoparticles through nose-only exposure chamber system developed by our group. Scanning mobility particle sizer (SMPS) analysis revealed that the mice were exposed to FMNPs with a total particle number of 4.89 ~ 10^5 } 2.37 ~ 10^/cm3 (low concentration) and 9.34 ~ 10^ 5} 5.11 ~ 10^4/cm3 (high concentration) for 4 wk (4 h/d, 5 d/wk). The body distribution of FMNPs was examined by magnetic resonance imaging (MRI) and Confocal Laser Scanning Microscope (CLSM) analysis. FMNPs were distributed in various organs, including the liver, testis, spleen, lung and brain. T2-weighted spin-echo MR images showed that FMNPs could penetrate the blood-brain-barrier (BBB). Application of nanotechnologies should not
produce adverse effects on human health and the Rapid Communication environment. To predict and prevent the potential toxicity of nanomaterials, therefore, extensive studies should be performed under different routes of exposure
with different sizes and shapes of nanomaterials.