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J Occup Health year 2008 volume 50 number 6 page 471 - 479
Classification Originals
Title Oral Toxicity of Indium in Rats: Single and 28-Day Repeated Administration Studies 
Author Keiko ASAKURA1, Hiroshi SATOH2, Momoko CHIBA3, Masahide OKAMOTO4, Koji SERIZAWA4, Makiko NAKANO1 and Kazuyuki OMAE1
Organization 1Department of Preventive Medicine and Public Health, Keio University School of Medicine, 2Environmental Health Sciences, Tohoku University Graduate School of Medicine, 3School of Pharmaceutical Sciences, International University of Health and Welfare and 4Department of Packaging Technology Solutions, Production Engineering Research Laboratory, Hitachi Ltd., Japan
Keywords Indium, Oral toxicity, Rat
Correspondence

K. Asakura, Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan (e-mail: jzf01334@nifty.ne.jp)

Abstract Oral Toxicity of Indium in Rats: Single and 28-Day Repeated Administration Studies: Keiko ASAKURA, et al. Department of Preventive Medicine and Public Health, Keio University School of Medicine-Indium is widely used in the electronics industry to make semiconductors, liquid-crystal panels, and plasma display panels, and its production is increasing. However, it is necessary to handle it more cautiously than before, because the pulmonary toxicity of inhaled indium has been identified. The present study aimed to characterize the potential toxic effects of indium through oral administration and observation for fourteen days following a single dose of 0 or 2,000 mg/kg (acute oral toxicity study), and repeated oral administration for 28 days at dose levels of 0, 40, 200, or 1,000 mg/kg daily (28-day repeated oral dose toxicity study) to male and female Crj:CD (SD) IGS rats (SPF). No deaths and no abnormalities in clinical signs, body weights, and necropsy findings were observed for any of the animals in the acute oral toxicity study. Furthermore, no changes related to indium were also observed in the dose groups up to 1,000 mg/kg of the 28-day repeated oral dose toxicity study. From the results described above, the lethal dose 50% (LD50) of indium is greater than 2,000 mg/kg under these study conditions, and the no-observed-adverse-effect-level (NOAEL) is considered to be 1,000 mg/kg for males and females under these conditions.